Dynamiker Biotechnology (Tianjin) Co., Ltd.
Aspergillosis

Aspergillosis Detection Kits | Dynamiker

Aspergillosis is a group of infections caused by Aspergillus fungi, often affecting immunocompromised individuals. It can present as allergic, chronic, or invasive illnesses, most commonly affecting the lungs. Invasive aspergillosis is a major, life-threatening opportunistic infection, and early diagnosis and antifungal treatment are crucial.
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Panel Testing of Aspergillus Ag and Ab for Early Diagnosis of Different Types of Aspergillosis

1. Invasive aspergillosis (IA)

  • Patient portrait: patients with neutropenia/severe immunosuppression

  • Clinical symptoms: fever, respiratory failure, hemoptysis, involvement of organs with abundant blood supply (heart, liver, kidney, brain, gastrointestinal tract, etc.)

  • Radiography: halo sign, inflammatory lesion, air bronchogram, air crescent sign, nodular,necrosis cavities

2.Chronic pulmonary aspergillosis (CPA)

  • Patient portrait: patients with neutropenia/severe immunosuppression

  • Allergic bronchopulmonary aspergillosis (ABPA)

  • Clinical symptoms: chronic cough, dyspnea, chest discomfort, occasional hemoptysis

  • Radiography: aspergilloma, cavity, nodular shadow, progressive solid "cyst", severestructural damage due to fibrosis in lung lobe

3.Allergic bronchopulmonary aspergillosis (ABPA)

  • Patient portrait: patients with asthma, cystic fibrosis, or COPD

  • Clinical symptoms: acute attacks accompanied by intractable wheezing, fever,cough, thick sputum or purulent sputum, occasional presence of brownish-yellow sputum bolts or sputum with blood; chronic stages presenting symptoms and signs of pulmonary fibrosis and bronchiectasis

  • Radiography: migratory patchy infiltrative shadow, transient lobar or segmental atelectasis, central bronchiectasis, allergic exogenous alveolitis showing diffused ground-glass interstitial lesion,chronic stages showing fibrosis or accompanied by honeycomb lung formation


Panel Testing of Aspergillus Ag and Ab for Early Diagnosis of Different Types of Aspergillosis

How Does Dynamiker's Test Kit Perform in Aspergillosis-Related Testing?

Based on an innovative ""5G+Pro"" panel testing solution in the industry, we typically employ a panel testing of Aspergillus Ag and Ab to facilitate early diagnosis of aspergillosis.

1.GM+Asp.IgG/IgE testing covers more patients infected with Aspergillus.

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2.The literature indicates that GM+Asp.IgG/IgE testing can greatly improve the sensitivity of detection.

TestGM(%)Asp. Ab(%)BDG+GM+Asp.Ab(%)
PatientsSensitivitySpecificitySensitivitySpecificitySensitivitySpecificity
Non-neutropenic IPA48.891.375.695.797.665.2

Dobias R, Jaworska P, Tomaskova H, Kanova M, Lyskova P, Vrba Z, Holub C, Svobodová L, Hamal P, Raska M. Diagnostic value of serum galactomannan, (1,3)-β-d-glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients. Mycoses. 2018 Aug;61(8):576-586. doi: 10.1111/myc.12765. Epub 2018 Jun 11. PMID: 29575150.

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