With the wide application of broad-spectrum antibiotics, corticosteroid, immunosuppressant, anti-tumor drugs, as well as the prevalence of AIDS and the development of organ transplantation, Invasive Fungal Diseases (IFD) cases are increasing and becoming more complicated. Candida species are the fourth most common cause of all nosocomial bloodstream infections (BSI). Nearly 50% of mortality is attributed to such infections. Appropriate initial antimicrobial therapy plays critical role in Invasive Candidiasis (IC) management and delay in the initiation of therapy would significantly increase the mortality of IC. The presence of mannan antigen against Candida indicates a prior Candida infection.
1.Microplate reader detection at 405nm using kinetic chromogenic method: Matches with international standard.
2.High throughput and rapid detection: It takes only 40 minutes to complete diagnosis for 90 sets of samples
(1-3)-β-D-glucan is widely present in the fungal cell wall and acts as a specific biomarker for fungal infection. The glucan specifically binds to factor G in the Main Reagent, activating its serine protease zymogen. The cascade of reactions changes the absorbance of the substrate and quantifies the (1-3)-β-D-glucan concentration.