Candida albicans is an opportunistic pathogen that inhabits the skin, mouth, gastrointestinal tract and vagina. It is the most commonly-isolated yeast in invasive candidiasis (IC) and occupies more than 65% of IC . Candida albicans can adhere to host tissues, produce secretory aspartyl proteases and phospholipase enzymes, and transform from yeast to hyphal phase, which is the major determinant of its pathogenicity. Risk factors for infections with Candida albicans include immunosuppression prior to steroid use, leukocytosis, intensive care unit stays, or presence of intravascular or urinary catheters.
Candida species are the fourth most common cause of all nosocomial bloodstream infections (BSIs). Nearly 50% of mortality is attributable to such infections. Appropriate initial antimicrobial therapy plays critical role in IC management and delay in the initiation of therapy would significantly increase the mortality of IC. The presence of IgG antibodies against Candida albicans indicates prior Candida albicans infection and suggests immunity. A significant rise of IgG levels indicates an acute infection or a re-infection.
1.Microplate reader detection at 405nm using kinetic chromogenic method: Matches with international standard.
2.High throughput and rapid detection: It takes only 40 minutes to complete diagnosis for 90 sets of samples
(1-3)-β-D-glucan is widely present in the fungal cell wall and acts as a specific biomarker for fungal infection. The glucan specifically binds to factor G in the Main Reagent, activating its serine protease zymogen. The cascade of reactions changes the absorbance of the substrate and quantifies the (1-3)-β-D-glucan concentration.